ABSTRACT
Aim: Aim is to depict suggestive urine and stool parameters in asymptomatic suspected contact children living with COVID-19 infected adults. These parameters will facilitate identifying children who deserve the confirmatory diagnosis of COVID-19 by PCR test. Methods: Study was conducted in the National Hepatology and Tropical Medicine Research institute (NHTMRI) Cairo, Egypt. It included 66 mild COVID-19 adult patients (group1) and their 82 asymptomatic contact children (group 2). Results: In group 1, both C reactive protein (CRP) and D-dimer levels were significantly high. C reactive protein was significantly positively correlated with urinary microalbumin> 30, albumin/ creatinine ratio and urine pus >10 cells / HPF and significantly negatively correlated with vitamin C. D-dimer was significantly negatively correlated with vitamin C. In group 2, CRP and D-dimer were significantly negatively correlated with urine specific gravity (SG), urinary vitamin C. CRP was significantly negatively correlated with stool pus > 10 cells/ HPF, while D-dimer was significantly positively correlated with stool occult blood. Receiver Operating Curve (ROC) analysis revealed that urine SG showed the highest area under the curve (AUC);0.859, 0.96, sensitivity of 100%, 100% and specificity of 71.8%, 77.8% with reference to D-dimer and CRP;respectively. Conclusions: In contact children of adult COVID-19 proved infection, urine SG, stool occult blood and stool pus > 10 cells/ HPF can be feasible tool for suspected COVID-19 infection, based on its results COVID-19 PCR request can be an imperative option to confirm the diagnosis;particularly in developing countries where detection of COVID-19 by PCR is not readily feasible. © 2020 The author (s). Published by Zagazig University.
ABSTRACT
Background: The novel corona virus disease 2019 (COVID-19) current pandemic is an unpreceded global health crisis. Not only infection of infants, children, and adolescents is a concern for their families and pediatricians, but there are also other serious challenges that should be properly identified and managed as well. Main body: We have to identify and assess the different factors that have either direct or indirect effects on child health and healthcare due to COVID-19 pandemic and focus on the serious effects. It is easily realized that there are many challenging problems associated with COVID-19 with short-term effects that already appeared and need urgent solutions and long-term effects that are not yet well apparent and have to be searched for and properly addressed. Conclusions: COVID-19 crisis has lots of impacts on child health and child healthcare, not only from the medical aspect but also from the social, psychological, economic, and educational facets. All these adverse implications have to be identified and dealt with on individual bases approach in the short and long term.